The Fischer Group - Programmable RNA Systems Lab
We combine fundamental nuclear RNA biology with synthetic RNA engineering to design programmable RNA systems that sense cellular state and precisely control gene expression for biomedical applications.
Research themes
About
The Programmable RNA Systems Lab studies how RNA is regulated, processed, and surveilled in the nucleus, and applies this mechanistic understanding to engineer programmable RNA systems for cell-specific control of gene expression.
Our work spans fundamental nuclear RNA biology, including non-coding RNAs, RNA surveillance, R-loops, and RNA-chromatin interactions, as well as synthetic RNA engineering approaches such as ribozyme-based sensing and logic-gated mRNA activation. The long-term goal is to develop precision RNA platforms for biomedical and therapeutic applications, with a particular focus on personalised cancer strategies.
Enquiries are welcome from potential Honours or PhD students. Please contact us.
Projects
Members
Leader
Group Leader - The Fischer Group
Technician
Technical Officer
Student
PhD Student
Honours Student
PhD Student
PhD Student
News
New research provides insight into how cells identify and discard faulty molecular machines responsible for RNA splicing.
Creating a historic moment for the John Curtin School of Medical Research (JCSMR), two of our outstanding PhD students Sasanan and Rakshanya claimed the winner and runner-up awards at the Australian National University (ANU) 3-Minute Thesis Competition 2024 grand finale, held on 25 July at Llewellyn Hall.
Andrew Zeller, Dan Palmer, Fiona Lewis and Sandali Seneviratne have had a big year conducting their Honours research at The John Curtin School of Medical Research. They share the highlights of a stressful, but rewarding journey.